Sertraline: Side effects

Sertraline is used to help balance the levels of serotonin in the brain. These medicines are thought to work by increasing the activity of the chemical called serotonin in the brain. There is a high risk of side effects here compared to other medications, so it is important to monitor your condition closely to help your doctor make crucial decisions regarding dose size to avoid these side effects.



Anyone can develop depression. It can develop for no apparent reason or it may be triggered by a life event such as a relationship problem, bereavement, or illness.

Sertraline may also be used for purposes not listed in this medication guide.

You should not use Sertraline if you are allergic to it, if you also take pimozide, or if you are being treated with methylene blue injection.

To make sure Sertraline is safe for you, tell your doctor if you have:

  •  liver or kidney disease;
  •  seizures or epilepsy;
  •  a bleeding or blood clotting disorder;
  •  bipolar disorder (manic depression); or
  •  a history of drug abuse or suicidal thoughts.

Common side effects may include


  • drowsiness, dizziness, tired feeling;
  • mild nausea, stomach pain, upset stomach, constipation;
  • dry mouth;
  • changes in appetite or weight;
  • sleep problems (insomnia); or
  • decreased sex drive, impotence, or difficulty having an orgasm.